A taxane diterpenoid; inhibits calcium-induced microtubule depolymerization in vitro; increases vincristine accumulation in multidrug-resistant 2780AD ovarian cancer cells

Cephalomannine – 10 mg

Brand:
Cayman
CAS:
71610-00-9
Storage:
-20
UN-No:
Non-Hazardous - /

Cephalomannine is a taxane diterpenoid and a derivative of paclitaxel (Item No. 10461) that has been found in yew trees and taxol-producing fungi.{42881} It inhibits calcium-induced microtubule depolymerization in vitro and increases accumulation of vincristine (Item No. 11764) in multidrug-resistant 2780AD ovarian cancer cells.{42882}  

 

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SKU: 27878 - 10 mg Category:

Description

A taxane diterpenoid; inhibits calcium-induced microtubule depolymerization in vitro; increases vincristine accumulation in multidrug-resistant 2780AD ovarian cancer cells,

Formal name: αR-hydroxy-βS-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-benzenepropanoic acid, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester

Synonyms:  NSC 318735

Molecular weight: 831.9

CAS: 71610-00-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Cancer|Multidrug Resistance

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