An alkaloid with diverse biological activities; inhibits CYP2D6 and CYP3A4 in vitro (Kis = 54 and 355 μM

Cephaeline – 1 mg

Brand:
Cayman
CAS:
483-17-0
Storage:
-20
UN-No:
Non-Hazardous - 1544 / 6.1

Cephaeline is an alkaloid originally isolated from C. ipecacuanha with diverse biological activities.{36703,36704,36705,36706} It inhibits the cytochrome P450 (CYP) isoforms CYP2D6 and CYP3A4 in vitro (Kis = 54 and 355 μM, respectively).{36703} Cephaeline reduces Zika virus (ZIKV) NS1 protein expression in HEK293 cells (IC50 = 26.4 nM) and reduces viral titer in ZIKV-infected SNB-19 cells (IC50 = 3.11 nM).{36704} In vivo, cephaeline (2 mg/kg, i.p.) reduces serum viral load in ZIKV-infected Ifnar1-/- mice. It induces emesis in ferrets when administered at a dose of 0.5 mg/kg, an effect that is prevented by the serotonin (5-HT) receptor subtype 5-HT3 antagonist ondansetron.{36705} Cephaeline (1 mg/kg) also increases output of respiratory tract fluid in rabbits.{36706}  

 

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Description

An alkaloid with diverse biological activities; inhibits CYP2D6 and CYP3A4 in vitro (Kis = 54 and 355 μM, respectively); reduces ZIKV NS1 protein expression in HEK293 cells (IC50 = 26.4 nM); reduces viral titer in ZIKV-infected SNB-19 cells (IC50 = 3.11 nM); reduces serum viral load in ZIKV-infected Ifnar1-/- mice at 2 mg/kg; induces emesis in ferrets at 0.5 mg/kg; increases output of respiratory tract fluid in rabbits at 1 mg/kg

Formal name: (1R)-1-[[(2S,3R,11bS)-3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-2-yl]methyl]-1,2,3,4-tetrahydro-7-methoxy-6-isoquinolinol

Synonyms:  (-)-Cephaeline

Molecular weight: 466.6

CAS: 483-17-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Zika||Research Area|Neuroscience

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