Description
A multi-kinase inhibitor; inhibits Axl and c-MET (IC50s = 7 and 12 nM, respectively); inhibits Axl in 293GT cells expressing Axl and c-MET in NCI H1299 NSCLC cells (IC50s = 0.26 and 6 nM, respectively); inhibits TYRO3 and MER (IC50s = 3.5 and 1.89 nM, respectively); induces complete regression of tumors in an Axl/NIH3T3 mouse xenograft model at 0.3 mg/kg; induces tumor stasis and regression in an EBC-1 NSCLC mouse xenograft model at 3 and 10 mg/kg, respectively; reduces tumor growth in an MC38 mouse syngeneic model concomitantly with innate and adaptive immune cell activation
Formal name: N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl]-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo-5-pyrimidinecarboxamide
Synonyms: RXDX-106
Molecular weight: 588.6
CAS: 1437321-24-8
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling
