A dual inhibitor of FAK1 (IC50s = 2.0 and 80 nM for in vitro enzyme and cellular inhibition

CEP-37440 – 25 mg

Brand:
Cayman
CAS:
1391712-60-9
Storage:
-20
UN-No:
De Minimis - 3077 / 9

CEP-37440 is a dual inhibitor of focal adhesion kinase 1 (FAK1; IC50s = 2.0 and 80 nM for in vitro enzyme and cellular inhibition, respectively) and anaplastic lymphoma kinase (ALK; IC50s = 3.1 and 22 nM for in vitro enzyme and cellular inhibition, respectively).{33407,33408} It blocks the proliferation of inflammatory and triple-negative breast cancer cell lines but not normal breast epithelial cells.{33408} CEP-37440 reduces the growth and metastasis of breast cancer xenografts in mice when given by oral gavage.{33408}  

 

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SKU: 21278 - Category:

Description

A dual inhibitor of FAK1 (IC50s = 2.0 and 80 nM for in vitro enzyme and cellular inhibition, respectively) and ALK (IC50s = 3.1 and 22 nM for in vitro enzyme and cellular inhibition, respectively); blocks the proliferation of breast cancer cell lines in vitro or in vivo

Formal name: 2-[[5-chloro-2-[[(6S)-6,7,8,9-tetrahydro-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-N-methyl-benzamide

Synonyms: 

Molecular weight: 580.1

CAS: 1391712-60-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling

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