![An S1P1 modulator (EC50 = 1 nM in a [35S]GTPɣS binding assay); selective for S1P1 over S1P2](https://interpriseusa.com/wp-content/uploads/2021/06/29665.png)
Description
An S1P1 modulator (EC50 = 1 nM in a [35S]GTPɣS binding assay); selective for S1P1 over S1P2, -3, -4, and -5 (EC50s = >10,000, 228, 2,137, and 36 nM, respectively); decreases TGF-β-induced increases in collagen levels in primary mouse skin fibroblasts at 5 µM; inhibits CD4+ T cell, CD8+ T cell, and CD11b+ cell infiltration, reduces IL1b, Il6, and Il13 expression, as well as decreases fibrosis in the skin of a mouse model of sclerodermatous chronic graft versus host disease induced by allogenic bone marrow transplant at 10 mg/kg per day; reduces paralysis and spinal cord demyelination in a mouse model of EAE at 6 mg/kg per day for 32 days
Formal name: (2S)-3-[4-[5-(2-cyclopentyl-6-methoxy-4-pyridinyl)-1,2,4-oxadiazol-3-yl]-2-ethyl-6-methylphenoxy]-1,2-propanediol
Synonyms:
Molecular weight: 453.5
CAS: 1262414-04-9
Purity: ≥95%
Formulation: A crystalline solid
