A selective inhibitor of TAF1 bromodomain 2 (IC50 = 2.1 µM); synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells

CeMMEC13 – 500 µg

Brand:
Cayman
CAS:
1790895-25-8
Storage:
-20
UN-No:
Non-Hazardous - /

CeMMEC13 is an isoquinolinone that selectively inhibits the second bromodomain of TAF1 (IC50 = 2.1 µM).{31547} It does not bind to bromodomains of BRD4, BRD9, or CREBBP.{31547} CeMMEC13 synergizes with (+)-JQ1 (Item No. 11187) to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells.{31547}  

 

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SKU: 20224 - Category:

Description

A selective inhibitor of TAF1 bromodomain 2 (IC50 = 2.1 µM); synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells

Formal name: N-​(2,​3-​​dihydro-1,​4-​​benzodioxin​-​6-​yl)​-​1,​2-​​dihydro-​1-​​methyl-​2-​​oxo-4-​quino​linecarbox​amide

Synonyms: 

Molecular weight: 336.3

CAS: 1790895-25-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Chromatin Reader Interactions||Research Area|Epigenetics, Transcription, & Translation|Readers|Bromodomains

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