An antibiotic; active against various bacterial strains

Cellocidin – 25 mg

Brand:
Cayman
CAS:
543-21-5
Storage:
-20
UN-No:
Non-Hazardous - 3462 / 6.1

Cellocidin is an antibiotic originally isolated from S. chibaensis.{36482} It is active against various bacterial strains including M. tuberculosis and against the trypanosomes T. brucei and T. rhodesiense (IC50s = 150 and 30 ng/ml, respectively).{36482,24919} It inhibits proliferation of LCL1 and LCL2 cells transformed by Epstein-Barr virus (EBV), activates the c-Myc and NF-κB pathways in BC3 and LCL1 cells, and induces necrotic cell death in B cells infected with gammaherpes virus.{36480} Cellocidin (100-200 ppm) is protective against bacterial leaf blight in rice plants and inhibits α-ketoglutarate oxidation in X. oryzae, the bacterium that causes leaf blight, when used at a concentration of 1 ppm, suggesting that it inhibits the citric acid cycle.{36481} Formulations containing cellocidin have been used as agricultural pesticides.  

 

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SKU: 23637 - 25 mg Category:

Description

An antibiotic; active against various bacterial strains, including M. tuberculosis, and trypanosomes; inhibits proliferation of EBV-transformed cells, activates the c-Myc and NF-κB pathways in vitro, and induces necrotic cell death in gammaherpes virus-infected B cells; protective against bacterial leaf blight in rice plants (100-200 ppm); inhibits α-ketoglutarate in X. oryzae (1 ppm)

Formal name: 2-butynediamide

Synonyms:  Acetylenedicarboxylic Acid|NSC 38643|NSC 65381

Molecular weight: 112.1

CAS: 543-21-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Pesticides||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis||Research Area|Infectious Disease|Parasitic Diseases|African Sleeping Sickness||Research Area|Plant Biology|Phytoprotectants

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