A metabolite of celecoxib

Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide – 500 µg

Brand:
Cayman
CAS:
264236-79-5
Storage:
-20
UN-No:
Non-Hazardous - /

Celecoxib carboxylic acid acyl-β-D-glucuronide is a phase II metabolite of celecoxib (Item No. 10008672). Celecoxib is an anti-inflammatory compound from the diaryl heterocycle class that selectively inhibits cyclooxygenase-2 (COX-2; IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively).{11633,8926} Celecoxib carboxylic acid acyl-β-D-glucuronide is a minor metabolite, accounting for 2% of the administered dose in human urine and rat bile.{37044,37045}  

 

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Description

A metabolite of celecoxib

Formal name: β-D-glucopyranuronic acid, 1-[4-[1-[4-(aminosulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-5-yl]benzoate]

Synonyms: 

Molecular weight: 587.5

CAS: 264236-79-5

Purity: ≥95%

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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