A cephalosporin antibiotic; inhibits the growth of some clinical isolates of Corynebacterium

Cefepime (hydrochloride hydrate) – 1 g

Brand:
Cayman
CAS:
123171-59-5
Storage:
-20
UN-No:
Non-Hazardous - /

Cefepime is a broad-spectrum cephalosporin antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria.{38779,38780} It inhibits the growth of some clinical isolates of Corynebacterium, Streptococcus, and Staphylococcus (MIC90s = 0.03-8 μg/ml), but does not inhibit the growth of methicillin-resistant S. aureus (MRSA) or S. haemolyticus (MIC50s = >128 μg/ml).{38779} Cefepime inhibits the growth of some Citrobacter, Enterobacter, Klebsiella, Salmonella, Serratia, Shigella, and enteric bacilli species in addition to P. mirabilis and E. coli clinical isolates (MIC90s = ≤0.12-2 μg/ml).{38780} It also inhibits the growth of E. coli and Klebsiella strains that produce extended-spectrum β-lactamase (ESBL; MIC90s = 4 and 8 μg/mL, respectively) and of indole-positive Proteae (MIC90 = 0.25 μg/ml). Cefepime inhibits the growth of pneumococci strains (MICs = 0.5-2 mg/l) in vitro and in vivo in a mouse model of peritonitis (ED50s = 0.6-1.14 mg/kg).{38781} Formulations containing cefepime have been used in the treatment of a variety of bacterial infections.  

 

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SKU: 23633 - 1 g Category:

Description

A cephalosporin antibiotic; inhibits the growth of some clinical isolates of Corynebacterium, Streptococcus, and Staphylococcus (MIC90s = 0.03-8 μg/ml); inhibits the growth of some Citrobacter, Enterobacter, Klebsiella, Salmonella, Serratia, Shigella, and enteric bacilli species in addition to P. mirabilis and E. coli clinical isolates (MIC90s = ≤0.12-2 μg/ml); inhibits the growth of pneumococci strains (MICs = 0.5-2 mg/l) in vitro and in vivo in a mouse model of peritonitis (ED50s = 0.6-1.14 mg/kg)

Formal name: 1-[[(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-pyrrolidinium, monochloride, monohydrochloride, monohydrate

Synonyms: 

Molecular weight: 571.5

CAS: 123171-59-5

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Cephalosporins||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Food-borne Illnesses||Research Area|Infectious Disease|Bacterial Diseases|Shigellosis

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