A 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 (IC50 = 60 nM)

Cdk2 Inhibitor II – 500 µg

Brand:
Cayman
CAS:
222035-13-4
Storage:
-20
UN-No:
Non-Hazardous - /

The cyclin-dependent kinase 2 (Cdk2) works with cyclins A or E to regulate S phase and G2-M transition during the cell cycle.{15254} Cdk2 Inhibitor II is a 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 (IC50 = 60 nM).{24723} It is cell permeable, reversible, and ATP-competitive.{24723}  

 

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Description

A 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 (IC50 = 60 nM)

Formal name: 4-[2-(5-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazinyl]-benzenesulfonamide

Synonyms:  Cyclin-dependent kinase 2 Inhibitor II|SC-221409

Molecular weight: 395.2

CAS: 222035-13-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling||Research Area|Cell Biology|Cell Cycle

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