A CDK/CRK-specific kinase inhibitor (IC50s = 9-839 nM

CDK/CRK Inhibitor – 5 mg

Brand:
Cayman
CAS:
784211-09-2
Storage:
-20
UN-No:
Non-Hazardous - /

CDK/CRK inhibitor is an inhibitor of cyclin-dependent kinases (CDK) and CDK-related kinases (CRK) with IC50 values ranging from 9-839 nM in vitro.{33104} It is selective, exhibiting less than 20% inhibition of 60 non-CDK/CRK kinases, at a concentration of 1 μM. CDK/CRK inhibitor induces cell cycle arrest in the G1 phase, endoreduplication, and apoptosis in HCT116 cells. It exhibits broad anti-tumor activity with an average GI50 value of 50 value of 40 nM.  

 

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Description

A CDK/CRK-specific kinase inhibitor (IC50s = 9-839 nM, in vitro); selective, exhibiting less than 20% inhibition of 60 non-CDK/CRK kinases, at a concentration of 1 μM; induces cell cycle arrest in the G1 phase, endoreduplication, and apoptosis in HCT116 cells; exhibits broad anti-tumor activity with an average GI50 value of 50 = 40 nM)

Formal name: 1-(2,6-dichlorophenyl)-1,5-dihydro-6-[[4-(2-hydroxyethoxy)phenyl]methyl]-3-(1-methylethyl)-4H-pyrazolo[3,4-d]pyrimidin-4-one

Synonyms:  Cdk7 Inhibitor IV|Cyclin-dependent kinase 7 Inhibitor IV|Cyclin-dependent kinase/CDK-related kinase Inhibitor|RGB-286147

Molecular weight: 473.4

CAS: 784211-09-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling

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