Immunogen: Peptide from the C-terminal region of human CD45 • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) CD45 • Applications: IHC

CD45 (C-Term) Rabbit Monoclonal Antibody – 100 µl

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Cayman
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CD45 is a type I transmembrane glycoprotein that is encoded by the PTPRC gene in humans and is abundantly expressed on nucleated hematopoietic cells.{49671} It contains an extracellular region that binds to glycoproteins and exists in various isoforms in a cell type-, differentiation state-, and activation state-dependent manner.{49671,49676} CD45 also contains two highly conserved cytoplasmic protein tyrosine phosphatase domains that regulate intracellular signaling.{49671} CD45 functions as a negative or positive regulator of antigen receptor signaling in T and B cells through dephosphorylation of Src family kinases in a cell type- and differentiation state-dependent manner.{49676} It also dephosphorylates JAK kinases, inhibiting cytokine and chemokine signaling in leukocytes. Mutations in PTPRC are associated with severe combined immunodeficiency (SCID) in mice and humans.{49672,49673,49674} The number of CD45+ cells is increased in postmortem brain from patients with Alzheimer’s disease.{49675} Increased levels of the CD45 isoform CD45RO have been found on CD19+ lamina propria B cells isolated from patients with Crohn’s disease.{49676} Fluorescently labeled versions of CD45 have commonly been used as a pan leukocyte marker in flow cytometry. Cayman’s CD45 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.  

 

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SKU: 32236 - 100 µl Category:

Description

Immunogen: Peptide from the C-terminal region of human CD45 • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) CD45 • Applications: IHC, WB

Synonyms: LCA|Leukocyte Common Antigen|Ly-5|PTPRC

Immunogen: Peptide from the C-terminal region of human CD45

Formulation: 100 µl of protein A-affinity purified antibody

Isotype: IgG

Applications: IHC, WB

Origin:

Stability: 365 days

Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer|Immunology||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity

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