An orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM); a potent and selective inhibitor of Cdk8 and Cdk19 that alters Wnt pathway-regulated gene expression

CCT251545 – 1 mg

Brand:
Cayman
CAS:
1661839-45-7
Storage:
-20
UN-No:
Non-Hazardous - /

CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM).{34178} It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19.{30162} Through its effects on Cdk8 and Cdk19, CCT251545 alters Wnt pathway-regulated gene expression.{30162} It reduces tumor growth in COLO 205 human colon cancer xenografts after oral dosing (70 mg/kg bid) and in Wnt-dependent tumors.{34178,30162}  

 

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Description

An orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM); a potent and selective inhibitor of Cdk8 and Cdk19 that alters Wnt pathway-regulated gene expression,

Formal name: 8-[3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-2,8-diazaspiro[4.5]decan-1-one

Synonyms: 

Molecular weight: 421.9

CAS: 1661839-45-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling|Wnt Signaling||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cell Signaling|Wnt Signaling

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