An inhibitor of Hsf1-mediated transcription; binds to Pirin (Ki = 28 nM) and inhibits Hsf1-mediated induction of Hsp27 in U2OS cells (IC50 = 19 nM); inhibits growth of SKOV3 ovarian carcinoma cells (GI50 = 1.1 nM); reduces tumor volume in an SKOV3 mouse xenograft model at 20 mg/kg

CCT251236 – 25 mg

Brand:
Cayman
CAS:
1693731-40-6
Storage:
-20
UN-No:
Non-Hazardous - /

CCT251236 is an inhibitor of transcription mediated by heat shock factor 1 (Hsf1) that binds to Pirin (Ki = 28 nM) and inhibits Hsf1-mediated induction of heat shock protein 27 (Hsp27) in U2OS cells (IC50 = 19 nM).{47525} It inhibits growth of SKOV3 ovarian carcinoma cells (GI50 = 1.1 nM). CCT251236 (20 mg/kg) reduces tumor volume in an SKOV3 mouse xenograft model.  

 

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SKU: 27788 - 25 mg Category:

Description

An inhibitor of Hsf1-mediated transcription; binds to Pirin (Ki = 28 nM) and inhibits Hsf1-mediated induction of Hsp27 in U2OS cells (IC50 = 19 nM); inhibits growth of SKOV3 ovarian carcinoma cells (GI50 = 1.1 nM); reduces tumor volume in an SKOV3 mouse xenograft model at 20 mg/kg

Formal name: N-[5-[[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]amino]-2-methylphenyl]-2-[2-(1-pyrrolidinyl)ethoxy]-6-quinolinecarboxamide

Synonyms: 

Molecular weight: 552.6

CAS: 1693731-40-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer

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