A C-terminal fragment of CCK; inhibits binding of [3H]naloxone in rat cerebellum membranes (IC50 = 4 µM); inhibits electrically-stimulated contraction of isolated guinea pig ileum (IC50 = 17 µM)

CCK (27-33) (non-sulfated) – 1 mg

Brand:
Cayman
CAS:
47910-79-2
Storage:
-20
UN-No:
Non-Hazardous - /

CCK (27-33) is a C-terminal fragment of CCK (Item Nos. 23371 | 24404), a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety.{40607,40606} Non-sulfated CCK (27-33) inhibits binding of [3H]naloxone in rat cerebellum membranes (IC50 = 4 µM) and inhibits electrically-stimulated contraction of isolated guinea pig ileum (IC50 = 17 µM), an effect that can be reversed by naloxone.{39623} Unlike sulfated CCK (27-33), the non-sulfated form does not reduce exploratory behavior in mice when administered at doses up to 1 µmol/kg.{39624}  

 

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SKU: 24952 - 1 mg Category:

Description

A C-terminal fragment of CCK; inhibits binding of [3H]naloxone in rat cerebellum membranes (IC50 = 4 µM); inhibits electrically-stimulated contraction of isolated guinea pig ileum (IC50 = 17 µM)

Formal name: L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide

Synonyms:  Cholecystokinin (27-33) (non-sulfated)

Molecular weight: 948.1

CAS: 47910-79-2

Purity: ≥95%

Formulation: A lyophilized powder

Product Type|Biochemicals|Peptides|Neuropeptides||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Neuroscience|Behavioral Neuroscience|Anxiety

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