An inhibitor of the Rho/MRTF/SRF transcriptional pathway; a derivative of CCG-203971; inhibits MRTF-dependent transcription in HEK293T cells (IC50 = 0.55 µM in a luciferase reporter assay); reduces expression of α-SMA in TGF-β-stimulated human dermal fibroblasts to 31% of control at 10 µM; inhibits increases in dermal thickness and hydroxyproline content in a mouse model of bleomycin-induced dermal fibrosis at 50 mg/kg

CCG-232601 – 1 mg

Brand:
Cayman
CAS:
1922099-21-5
Storage:
-20
UN-No:
Non-Hazardous - /

CCG-232601 is an inhibitor of the Rho/MRTF/SRF transcriptional pathway and a derivative of CCG-203971 (Item No. 15075).{35196} CCG-232601 inhibits MRTF-dependent transcription in HEK293T cells (IC50 = 0.55 µM in a luciferase reporter assay). It also reduces expression of α-smooth muscle actin (α-SMA) in TGF-β-stimulated human dermal fibroblasts to 31% of control when used at a concentration of 10 µM. CCG-232601 (50 mg/kg) inhibits increases in dermal thickness and hydroxyproline content in a mouse model of dermal fibrosis induced by bleomycin (Item No. 13877).  

 

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SKU: 24382 - 1 mg Category:

Description

An inhibitor of the Rho/MRTF/SRF transcriptional pathway; a derivative of CCG-203971; inhibits MRTF-dependent transcription in HEK293T cells (IC50 = 0.55 µM in a luciferase reporter assay); reduces expression of α-SMA in TGF-β-stimulated human dermal fibroblasts to 31% of control at 10 µM; inhibits increases in dermal thickness and hydroxyproline content in a mouse model of bleomycin-induced dermal fibrosis at 50 mg/kg

Formal name: N-(4-chlorophenyl)-5,5-difluoro-1-[3-(4-pyridinyl)benzoyl]-3-piperidinecarboxamide

Synonyms: 

Molecular weight: 455.9

CAS: 1922099-21-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Transcription Factors||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation

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