A mitochondrial uncoupler; inhibits mitochondrial respiration and ATPase activity when used at concentrations of 110 and 35 nM

CCCP – 250 mg

Brand:
Cayman
CAS:
555-60-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

CCCP is a protonophore mitochondrial uncoupler that increases membrane permeability to protons, leading to a disruption in the mitochondrial membrane potential.{39958} It inhibits mitochondrial respiration and ATPase activity when used at concentrations of 110 and 35 nM, respectively.{39959} CCCP inhibits activation of stimulation of interferon genes (STING), decreasing the expression of downstream STING targets, including IFN-β, TBK1, and IRF3 when used at a concentration of 50 µM in RAW 264.7 cells.{39960} It induces mitochondrial fission in a manner dependent on the GTPase Drp1. CCCP (4 mg/kg) increases body temperature as well as left ventricular systolic and diastolic dimensions and decreases fractional shortening in rats.{39961} It also increases myocardial glucose and fatty acid uptake in rats.  

 

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SKU: 25458 - 250 mg Category:

Description

A mitochondrial uncoupler; inhibits mitochondrial respiration and ATPase activity when used at concentrations of 110 and 35 nM, respectively; inhibits activation of STING at 50 µM; increases body temperature as well as left ventricular systolic and diastolic dimensions and decreases fractional shortening in rats at 4 mg/kg

Formal name: 2-[2-(3-chlorophenyl)hydrazinylidene]-propanedinitrile

Synonyms:  Carbonyl cyanide m-chlorophenyl hydrazone|NSC 88124

Molecular weight: 204.6

CAS: 555-60-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Cardiovascular System|Heart||Research Area|Cell Biology|Mitochondrial Biology

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