Description
A dual inhibitor of Mps1/TTK and Clk2 (IC50s = 5 and 3 nM, respectively); selective for Mps1/TTK and Clk2 over a panel of 255 kinases at 3 μM; inhibit DYRK3, DYRK1A, PHKG, DYRK1B, and Clk1 (IC50s = 99, 104, 136, 157, and 300 nM, respectively); selectively inhibits the growth of Cal-51 TNBC cell over BT-474 luminal breast cancer cells (IC50s = 60 and 6,970 nM, respectively); reduces tumor volume in a Cal-51 mouse xenograft model at 20 mg/kg
Formal name: 4-[[4-(cyclopentyloxy)-5-(2-methyl-6-benzoxazolyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxy-N-methyl-benzamide
Synonyms:
Molecular weight: 512.6
CAS: 1618658-88-0
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling
