A small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 µM); blocks CBFβ-Runx1 interactions in ME-1 cells

CBFβ Inhibitor – 25 mg

Brand:
Cayman
CAS:
493028-20-9
Storage:
-20
UN-No:
Non-Hazardous - /

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ.{27439} CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias.{27439,27440} CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 µM).{27441} It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.{27441}  

 

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Description

A small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 µM); blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity

Formal name: 5-ethyl-4-(4-methoxyphenyl)-2-thiazolamine

Synonyms:  Core Binding Factor-β Inhibitor

Molecular weight: 234.3

CAS: 493028-20-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer

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