A dual agonist of the CB1 (IC50 = 15 nM) and CB2 (IC50 = 98 nM) receptors; potently blocks CB1-dependent neuropathic mechanical hyperalgesia in rats

CB-13 – 10 mg

Brand:
Cayman
CAS:
432047-72-8
Storage:
-20
UN-No:
Non-Hazardous - /

CB-13 is a dual agonist of the CB1 (IC50 = 15 nM) and CB2 (IC50 = 98 nM) receptors.{14984} In rats, oral CB-13 (3 mg/kg) potently blocks CB1-dependent neuropathic mechanical hyperalgesia, shows limited brain penetration, and exhibits good oral bioavailability.{14984} CB-13 does not possess genotoxic potential, as indicated by negative results in both chromosome aberration and reverse mutation assays.{14984} The effects of CB-13 on other aspects of CB signaling have not been assessed.  

 

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SKU: 10010398 - 10 mg Category:

Description

A dual agonist of the CB1 (IC50 = 15 nM) and CB2 (IC50 = 98 nM) receptors; potently blocks CB1-dependent neuropathic mechanical hyperalgesia in rats, shows limited brain penetration, and exhibits good oral bioavailability

Formal name: 1-naphthalenyl[4-(pentylox)-1-naphthalenyl]-methanone

Synonyms:  CRA-13

Molecular weight: 368.5

CAS: 432047-72-8

Purity: ≥98%

Formulation: A crystalline solid

Application||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors||Research Area|Neuroscience|Pain Research

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