An anticancer compound; inhibits proliferation of a panel of melanoma and breast

CAY10736 – 1 mg

Brand:
Cayman
CAS:
2251753-61-2
Storage:
-20
UN-No:
Non-Hazardous - /

CAY10736 is an anticancer compound.{48452} It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal transition (EMT) of A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 2.4 and 1.59 μM, respectively) and increases the production of reactive oxygen species (ROS) in these cells in a concentration-dependent manner. CAY10736 (5 mg/kg) reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model.  

 

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SKU: 26754 - 1 mg Category:

Description

An anticancer compound; inhibits proliferation of a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM); inhibits migration and EMT of A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner; reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 2.4 and 1.59 μM, respectively) and increases the production of ROS in these cells in a concentration-dependent manner; reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model at 5 mg/kg

Formal name: N-[2-[[[(4-methoxyphenyl)amino]thioxomethyl]amino]ethyl]-2-methylene-3-oxo-olean-12-en-28-amide

Synonyms:  Compound 51

Molecular weight: 674

CAS: 2251753-61-2

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Research Area|Cancer|Tumor Microenvironment

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