An arylurea fatty acid; decreases proliferation and initiates apoptosis in MDA-MB-231 cells via depletion of the phospholipid cardiolipin and and its precursor phosphatidylglycerol from the mitochondrial membrane; reduces tumor volume and increases tumor cell apoptosis in a mouse MDA-MB-231 breast cancer xenograft model in a dose-dependent manner when administered at doses ranging from 2.5 to 40 mg/kg

CAY10726 – 1 mg

Brand:
Cayman
CAS:
1611446-66-2
Storage:
-20
UN-No:
Non-Hazardous - /

CAY10726 is an arylurea fatty acid.{40512} It decreases ATP production by 28% in MDA-MB-231 breast cancer cells when used at a concentration of 10 μM. CAY10726 decreases proliferation and initiates apoptosis in MDA-MB-231 cells via depletion of the phospholipid cardiolipin and its precursor phosphatidylglycerol from the mitochondrial membrane. In vivo, CAY10726 (2.5-40 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a mouse MDA-MB-231 breast cancer xenograft model in a dose-dependent manner.  

 

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SKU: 23859 - 1 mg Category:

Description

An arylurea fatty acid; decreases proliferation and initiates apoptosis in MDA-MB-231 cells via depletion of the phospholipid cardiolipin and and its precursor phosphatidylglycerol from the mitochondrial membrane; reduces tumor volume and increases tumor cell apoptosis in a mouse MDA-MB-231 breast cancer xenograft model in a dose-dependent manner when administered at doses ranging from 2.5 to 40 mg/kg

Formal name: 16-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-hexadecanoic acid

Synonyms: 

Molecular weight: 493

CAS: 1611446-66-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Lipid Biochemistry|Fatty Acids

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