A PAD2 inhibitor; binds to PAD2 in a target engagement assay (EC50 = 9.5 μM in HEK293/PAD2 cells); 1.6-

CAY10723 – 1 mg

Brand:
Cayman
CAS:
2095107-57-4
Storage:
-20
UN-No:
Non-Hazardous - /

CAY10723 is an inhibitor of protein arginine deiminase 2 (PAD2) that binds to PAD2 in a target engagement assay (EC50 = 9.5 μM in HEK293/PAD2 cells).{36047} It is 1.6-, 47-, and ~15-fold selective for PAD2 over PAD1, PAD3, and PAD4, respectively. CAY10723 inhibits histone H3 citrullination in HEK293/PAD2 cells (EC50 = 0.4 μM).  

 

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Description

A PAD2 inhibitor; binds to PAD2 in a target engagement assay (EC50 = 9.5 μM in HEK293/PAD2 cells); 1.6-, 47-, and ~15-fold selective for PAD2 over PAD1, PAD3, and PAD4, respectively; inhibits histone H3 citrullination in HEK293/PAD2 cells (EC50 = 0.4 μM)

Formal name: N-[(1S)-4-[(2-fluoro-1-iminoethyl)amino]-1-(4-methoxy-1-methyl-1H-benzimidazol-2-yl)butyl]-2,3-dihydro-3-oxo-1H-isoindole-4-carboxamide

Synonyms:  ,AMF30a

Molecular weight: 466.5

CAS: 2095107-57-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deiminases||Research Area|Epigenetics, Transcription, & Translation|Writers|Citrullination

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