An orally bioavailable inhibitor of mPGES-1 (IC50 = 0.24 µM in an in vitro human whole blood assay); inactive against COX-1 and COX-2 (9% inhibition at 100 µM and 16% at 30 µM

CAY10700 – 5 mg

Brand:
Cayman
CAS:
1381846-21-4
Storage:
-20
UN-No:
Non-Hazardous - /

Prostaglandin E2 (PGE2; Item No. 14010) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE2 during inflammation can be accounted for by increased expression of both COX-2 and microsomal PGE synthase-1 (mPGES-1). CAY10700 is an orally bioavailable inhibitor of mPGES-1 (IC50 = 0.24 µM in an in vitro human whole blood assay).{30657} It is inactive against COX-1 and COX-2 (9% inhibition at 100 µM and 16% at 30 µM, respectively).{30657}  

 

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Description

An orally bioavailable inhibitor of mPGES-1 (IC50 = 0.24 µM in an in vitro human whole blood assay); inactive against COX-1 and COX-2 (9% inhibition at 100 µM and 16% at 30 µM, respectively)

Formal name: 2-​chloro-​5-​[[(2,​2-​dimethyl-​1-​oxopropyl)​amino]​methyl]​-​N-​1H-​imidazol-​2-​yl-benzamide

Synonyms: 

Molecular weight: 334.8

CAS: 1381846-21-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Prostaglandin Synthases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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