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CAY10662 – 100 µg

Brand:
Cayman
CAS:
1184844-74-3
Storage:
-20
UN-No:
De Minimis - 1230 / 3|6.1

17(R),18(S)-Epoxyeicosatetraenoic acid (17(R),18(S)-EpETE), a natural cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid, is known to reduce the contraction rate of spontaneously beating heart cells and to protect neonatal rat cardiomyocytes against arrhythmias induced by β-adrenergic agonists (EC50 = ~ 1-2 nM).{19905} CAY10662 is a 1,3 disubstituted urea derivative of 17(R),18(S)-EpETE that is more metabolically robust and reduces the contractility of cardiomyocytes with improved potency (EC50 fold higher than required for the effect on cardiomyocytes, 1-5 μM CAY10662 exerts weak dose-dependent soluble epoxide hydrolase inhibition.{19905}  

 

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SKU: 11042 - 100 µg Category:

Description

A 1,3 disubstituted urea derivative of 17(R),18(S)-EpETE that is more metabolically robust and reduces the contractility of cardiomyocytes with improved potency (EC50 fold higher than required for the effect on cardiomyocytes, 1-5 μM CAY10662 exerts weak dose-dependent sEH inhibition

Formal name: 16-[[(ethylamino)carbonyl]amino]-11Z-hexadecenoic acid

Synonyms: 

Molecular weight: 340.5

CAS: 1184844-74-3

Purity: ≥98%

Formulation: A solution in methanol

Product Type|Biochemicals|Lipids|Fatty Acids||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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