A thiophene carboximide derivative proposed to inhibit IKK2; likely to be useful in the treatment of inflammatory diseases and cancer

CAY10657 – 10 mg

Brand:
Cayman
CAS:
494772-86-0
Storage:
-20
UN-No:
Non-Hazardous - /

The NF-κB/Rel family of transcription factors induce and coordinate the expression of pro-inflammatory genes including cytokines, chemokines, interferons, MHC proteins, growth factors, and cell adhesion molecules. Under resting conditions NF-κB dimers are retained in the cytoplasm by a member of the IκB family of inhibitory proteins. Upon activation by cytokines or other stimuli, IKK phosphorylates IκB, initiating a signaling cascade to activate gene transcription.{7136,8494,18544} CAY10657 is a thiophenecarboximide derivative proposed to inhibit IKK2.{20631} Currently, there are no published reports of its biological activity. However, inhibition of NF-κB activation is likely to be of broad utility in the treatment of inflammatory diseases and cancer.{17345,17344}  

 

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SKU: 11140 - 10 mg Category:

Description

A thiophene carboximide derivative proposed to inhibit IKK2; likely to be useful in the treatment of inflammatory diseases and cancer

Formal name: 3-[(aminocarbonyl)amino]-5-[4-(4-morpholinylmethyl)phenyl]-2-thiophenecarboxamide

Synonyms: 

Molecular weight: 360.4

CAS: 494772-86-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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