A synthetic analog of natural AHLs that suppresses host immunity without inducing LasR; inhibits the proliferation of mouse peripheral blood leukocytes by concanavalin A (EC50 = 9.3 μM) without concurrent cytotoxicity; does not induce LasR at 100 μM

CAY10654 – 10 mg

Brand:
Cayman
CAS:
1298023-69-4
Storage:
-20
UN-No:
Non-Hazardous - /

The gram-negative pathogen Pseudomonas aeruginosa uses N-acylated-L-homoserine lactones (AHLs) in quorum sensing to modulate transcriptional activators, including LasR, and regulate the expression of virulence factors. The same AHLs suppress the host immune system. CAY10654 is a synthetic analog of natural AHLs that suppresses host immunity without inducing LasR.{19410} It inhibits the proliferation of mouse peripheral blood leukocytes by concanavalin A (EC50 = 9.3 μM) without concurrent cytotoxicity.{19410} LasR is not induced by 100 μM CAY10654, although LasR is potently induced by natural AHL (5 μM) in positive control experiments.{19410}  

 

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SKU: 10857 - 10 mg Category:

Description

A synthetic analog of natural AHLs that suppresses host immunity without inducing LasR; inhibits the proliferation of mouse peripheral blood leukocytes by concanavalin A (EC50 = 9.3 μM) without concurrent cytotoxicity; does not induce LasR at 100 μM

Formal name: N’-(5-chloro-2-hydroxyphenyl)-N3-octylmalonamide

Synonyms: 

Molecular weight: 340.9

CAS: 1298023-69-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Homoserine Lactones||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Quorum Sensing

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