A highly potent (IC50 = 12 nM) cPLA2α inhibitor; demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis

CAY10650 – 1 mg

Brand:
Cayman
CAS:
1233706-88-1
Storage:
-20
UN-No:
Non-Hazardous - /

Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process.{14663} CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor.{18732} It demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis.{18732} The phase I metabolite of this compound, CAY10641 (Item No. 10662), is also available.  

 

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SKU: 10743 - 1 mg Category:

Description

A highly potent (IC50 = 12 nM) cPLA2α inhibitor; demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis

Formal name: 3-(2-methyl-1-oxopropyl)-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indole-5-carboxylic acid

Synonyms: 

Molecular weight: 471.5

CAS: 1233706-88-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Glycerophospholipids|Phospholipases

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