An inactive alcohol derivative of a highly potent (IC50 = 12 nM) cPLA2α inhibitor with strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis

CAY10641 – 1 mg

Brand:
Cayman
CAS:
1233706-89-2
Storage:
-20
UN-No:
Non-Hazardous - /

Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process.{14663} CAY10641 is an inactive alcohol derivative of a highly potent (IC50 = 12 nM) cPLA2α inhibitor. {18732} The parent compound demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis.{18732} CAY10641 is rapidly cleared from the blood stream (only 0.5 μg/ml remains 30 minutes after 10 mg/kg intravenous administration to mice).{18732} However, no other biological effects have been reported.  

 

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SKU: 10662 - 1 mg Category:

Description

An inactive alcohol derivative of a highly potent (IC50 = 12 nM) cPLA2α inhibitor with strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis

Formal name: 1-[2-hydroxy-3-(4-phenoxyphenoxy)propyl]-3-(2-methyl-1-oxopropyl)-1H-indole-5-carboxylic acid

Synonyms: 

Molecular weight: 473.5

CAS: 1233706-89-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phospholipases||Research Area|Immunology & Inflammation

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