An antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/DIABLO with an IC50 value of 2.2 µM; sensitizes cells to apoptotic stimuli

CAY10625 – 10 mg

Brand:
Cayman
CAS:
137346-42-0
Storage:
-20
UN-No:
Non-Hazardous - /

Survivin is a cellular protein implicated in cell survival by interacting with and inhibiting the apoptotic function of several proteins including Smac/DIABLO, caspase-3, and caspase-7.{18220,12862} Survivin also plays a role in the regulation of the cell cycle as part of a protein complex that includes INCENP, Aurora B kinase, and Borealin. CAY10625 is an antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/DIABLO, exhibiting an IC50 value of 2.2 µM.{18017} It inhibits the interaction of survivin with INCENP less effectively with an IC50 value of 20 µM. CAY10625 is cell-permeable and sensitizes cells to the induction of apoptosis by doxorubicin.{18017}  

 

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Description

An antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/DIABLO with an IC50 value of 2.2 µM; sensitizes cells to apoptotic stimuli

Formal name: 7-nitro-10-octyl-3-phenyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione

Synonyms: 

Molecular weight: 446.5

CAS: 137346-42-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cell Death|Apoptosis

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