A potent

CAY10606 – 5 mg

Brand:
Cayman
CAS:
1159576-98-3
Storage:
-20
UN-No:
Non-Hazardous - /

5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10606 is a potent, reversible inhibitor of 5-LO, both in cell-free assays (IC50 = 86 nM) and in intact neutrophils (IC50 = 230 nM).{17244} It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 (IC50 = 1.6 μM) or formyl peptide (fMLP) following priming with lipopolysaccharide (IC50 = 830 nM). In rats subjected to carrageenan-induced pleurisy, CAY10606 significantly reduces both LT biosynthesis and the inflammatory reaction.{17244}  

 

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Description

A potent, reversible inhibitor of 5-LO, in cell-free assays (IC50 = 86 nM), intact neutrophils (IC50 = 230 nM), and in whole blood (IC50 = 830 nM); significantly reduces both LT biosynthesis and inflammatory reactions in rats subjected to carrageenan-induced pleurisy

Formal name: 2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester

Synonyms: 

Molecular weight: 379.8

CAS: 1159576-98-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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