A PPARγ agonist that is 4-fold more potent than rosiglitazone at the PPARγ receptor demonstrating an EC50 value of 0.05 µM; shows high selectivity for PPARγ over PPARα (EC50 = 3.99 µM) or PPARδ (EC50 > 10 µM)

CAY10599 – 5 mg

Brand:
Cayman
CAS:
1143573-33-4
Storage:
-20
UN-No:
Non-Hazardous - /

Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions in vivo.{7575,8930} The prototypical compound for this class is the TZD rosiglitazone (BRL 49653), which is currently marketed for the treatment of diabetes. CAY10599 is a PPARγ agonist that is 4-fold more potent than rosiglitazone at the PPARγ receptor demonstrating an EC50 value of 0.05 µM.{17110} This compound shows high selectivity for PPARγ over PPARα (EC50 = 3.99 µM) or PPARδ (EC50 > 10 µM).{17110}  

 

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Description

A PPARγ agonist that is 4-fold more potent than rosiglitazone at the PPARγ receptor demonstrating an EC50 value of 0.05 µM; shows high selectivity for PPARγ over PPARα (EC50 = 3.99 µM) or PPARδ (EC50 > 10 µM)

Formal name: 2-[[1-[3-[4-([1,1′-biphenyl]-4-ylcarbonyl)-2-propylphenoxy]propyl]-1,2,3,4-tetrahydro-5-quinolinyl]oxy]-2-methyl-propanoic acid

Synonyms: 

Molecular weight: 591.7

CAS: 1143573-33-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs

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