A selective FFAR1 (GPR40) agonist (EC50 = 32nM) that does not exhibit activity on the related FFARs: FFAR2 (GPR43) or FFAR3 (GPR41); increases glucose-stimulated insulin secretion at a concentration of 100 nM in the rat

CAY10587 – 25 mg

Brand:
Cayman
CAS:
1082058-99-8
Storage:
-20
UN-No:
De Minimis - 3077 / 9

The free fatty acid receptor 1 (FFAR1; GPR40) is highly expressed in pancreatic β-cells and activated by medium and long-chain fatty acids.{13138} There is evidence of a link between FFAR1 (GPR40) and the ability of fatty acids to amplify glucose-stimulated insulin secretion, making this signaling pathway a potential target for regulating diabetes, obesity, and other metabolic disorders.{13139,14742} CAY10587 is a selective FFAR1 (GPR40) agonist (EC50 = 32 nM) that does not exhibit activity on the related FFARs: FFAR2 (GPR43) or FFAR3 (GPR41).{16584} At 100 nM, CAY10587 increases glucose-stimulated insulin secretion in the rat insulin-secreting cell line INS-1E.{16584}  

 

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Description

A selective FFAR1 (GPR40) agonist (EC50 = 32nM) that does not exhibit activity on the related FFARs: FFAR2 (GPR43) or FFAR3 (GPR41); increases glucose-stimulated insulin secretion at a concentration of 100 nM in the rat

Formal name: 4-[2-(2-methylphenyl)ethynyl]-benzenepropanoic acid

Synonyms: 

Molecular weight: 264.3

CAS: 1082058-99-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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