An 8-aza-9-oxo-15-hydroxy saturated analog of PGE2; selectively binds the EP4 receptor (Ki = 35 nM) relative to the EP1

CAY10580 – 5 mg

Brand:
Cayman
CAS:
64054-40-6
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption,{16772} cancer,{16773} and atherosclerosis.{16619} CAY10580 is an 8-aza-9-oxo-15-hydroxy saturated analog of PGE2. It selectively binds the EP4 receptor (Ki = 35 nM) relative to the EP1, EP2, and EP3 receptors (Ki = 3,000, 2,000, and >3,000 nM, respectively).{16762} CAY10580 stimulates cAMP formation in excised mouse ovaries.{16763}  

 

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Description

An 8-aza-9-oxo-15-hydroxy saturated analog of PGE2; selectively binds the EP4 receptor (Ki = 35 nM) relative to the EP1, EP2, and EP3 receptors (Ki = 3,000, 2,000, and >3,000 nM, respectively); stimulates cAMP formation in excised mouse ovaries

Formal name: 2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid

Synonyms: 

Molecular weight: 341.5

CAS: 64054-40-6

Purity: ≥96%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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