A potent antiprion compound that inhibits the accumulation of PrPc with an IC50 value of 3 nM in both ScN2a and F3 prion-infected mouse neuroblastoma cell lines; also inhibits the formation of hydroxyl radicals in vitro with an IC50 value of 90 µM

CAY10550 – 10 mg

Brand:
Cayman
CAS:
34320-83-7
Storage:
-20
UN-No:
Non-Hazardous - /

Cellular prion protein (PrPc) is a cell surface glycoprotein expressed in brain, spinal cord, and several peripheral tissues that if mutated to the protease-resistant isoform PrPSc (scrapie PrP, PrPres) can result in one of several fatal neurodegenerative diseases.{10289} Prion diseases, including mad cow disease (bovine spongiform encephalopathy), scrapie, and Creutzfeldt-Jakob disease develop from the accumulation of PrPSc, an abnormally folded β-rich conformation of PrPc.{11676,7171} CAY10550 is a potent antiprion compound that inhibits the accumulation of PrPc with an IC50 value of 3 nM in both ScN2a and F3 prion-infected mouse neuroblastoma cell lines.{15077} This compound also demonstrates moderate radical scavenging activity as it inhibits the formation of hydroxyl radicals in vitro with an IC50 value of 90 µM.{15077}  

 

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SKU: 10010740 - 10 mg Category:

Description

A potent antiprion compound that inhibits the accumulation of PrPc with an IC50 value of 3 nM in both ScN2a and F3 prion-infected mouse neuroblastoma cell lines; also inhibits the formation of hydroxyl radicals in vitro with an IC50 value of 90 µM

Formal name: 2,4-dihydro-5-(4-nitrophenyl)-2-phenyl-3H-pyrazol-3-one

Synonyms:  3-(4-Nitrophenyl)-1-phenyl-2-pyrazolin-5-one

Molecular weight: 281.3

CAS: 34320-83-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Neuroscience|Neurodegenerative Disorders|Prion Disease

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