Description
The early stage of atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall. CAY10487 inhibits formation of fatty streak lesions of the thoracic aorta in high cholesterol-fed rabbits without affecting plasma lipid profiles or significantly inhibiting ACAT-1 or ACAT-2 activity.{12440,12441} The percent area occupied by the atherosclerotic lesion in rabbits supplemented with 0.05% CAY10487 in the diet was 16.1% compared to 53.5% in control rabbits.{12440} CAY10487 also exhibits antioxidant activity, inhibiting copper-mediated oxidation of LDL by about 75% at a concentration of 2 µM.{12441}
Formal name: N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester
Synonyms: 3,4-Dihydrocinnamic Acid (L-alanine methyl ester) amide
Molecular weight: 265.3
CAS: 778624-05-8
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Protein Oxidation
