An inhibitor of human ACAT-1 and ACAT-2 with an IC50 value of approximately 60 µM for both enzymes; also inhibits copper-mediated oxidation of LDL by about 20% at a concentration of 3 µM

CAY10486 – 10 mg

Brand:
Cayman
CAS:
615264-52-3
Storage:
-20
UN-No:
Non-Hazardous - /

Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis.{10960,11758} CAY10486 inhibits human ACAT-1 and ACAT-2 equally with an IC50 value of approximately 60 µM.{12441} It also inhibits copper-mediated oxidation of low density lipoproteins by about 28% at a concentration of 3 µM.{12441}  

 

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SKU: 10006452 - 10 mg Category:

Description

An inhibitor of human ACAT-1 and ACAT-2 with an IC50 value of approximately 60 µM for both enzymes; also inhibits copper-mediated oxidation of LDL by about 20% at a concentration of 3 µM

Formal name: N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester

Synonyms:  4-Hydroxycinnamic acid (L-phenylalanine methyl ester) amide

Molecular weight: 325.4

CAS: 615264-52-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism

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