A pro-apoptotic activator of the apoptosome; activates caspase-3 (EC50 = 5 µM) in a cell free

CAY10443 – 50 mg

Brand:
Cayman
CAS:
582314-48-5
Storage:
-20
UN-No:
Non-Hazardous - /

Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome.{6873} Library screens have identified small molecules that activate the apoptosome by binding to one or more of its components. CAY10443 is one such molecule. In a cell free, multi-component assay, it activated caspase-3 with an EC50 of 5 µM.{11535} These apoptotic activators represent therapeutic lead compounds for the development of antitumor drugs.  

 

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SKU: 10004177 - 50 mg Category:

Description

A pro-apoptotic activator of the apoptosome; activates caspase-3 (EC50 = 5 µM) in a cell free, multi-component assay,

Formal name: [(3,4-dichlorophenyl)methyl]-carbamic acid, (1S)-2,3-dihydro-1H-inden-1-yl ester

Synonyms:  (S)-Indan-1-yl 3,4-dichlorobenzylcarbamate

Molecular weight: 336.2

CAS: 582314-48-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Caspases||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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