A selective

CAY10435 – 10 mg

Brand:
Cayman
CAS:
288862-73-7
Storage:
-20
UN-No:
Excepted Quantity - 1231 / 3

Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10435 is a selective, potent inhibitor of rat FAAH exhibiting a Ki value of 0.57 nM.{8481} Using a proteonomics approach, CAY10435 was screened against the serine hydrolase family of enzymes, of which FAAH is a member. In this assay, CAY10435 exhibited IC50 values of 0.81 nM, 83 nM, and 50 µM for FAAH, triacylglycerol hydrolase (TGH), and an uncharacterized hydrolase (KIAA1363), respectively.{11817} Knowledge of the specificity of CAY10435 obtained from this experiment should allow for more accurate interpretation of results using the inhibitor in complex environments such as whole cells or animals.  

 

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SKU: 10005102 - 10 mg Category:

Description

A selective, potent inhibitor of rat FAAH (Ki = 0.57 nM); exhibited IC50 values of 0.81, 83 nM, and 50 µM for FAAH, TGH, and an uncharacterized hydrolase (KIAA1363), respectively, when screened against the serine hydrolase family of enzymes

Formal name: 1-oxaxolo[4,5-b]pyridin-2-yl-1-dodecanone

Synonyms: 

Molecular weight: 302.4

CAS: 288862-73-7

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Small Molecule Inhibitors|Fatty Acid Metabolism||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Lipid Biochemistry|Glycerolipids||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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