CAY10410 is an analog of PGD2/PGJ2 with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-.DELTA.12

CAY10410 – 1 mg

Brand:
Cayman
CAS:
596104-94-8
Storage:
-20
UN-No:
De Minimis - 1231 / 3

CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-Δ12,14-PGJ2 has been shown to be a potent ligand for PPARγ.{1424} Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and Δ12-PGJ2 occurs via glutathione addition across the α,β unsaturated enone.{7193} CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 µM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 µM.{12676}  

 

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Description

CAY10410 is an analog of PGD2/PGJ2 with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-.DELTA.12,14-PGJ2 has been shown to be a potent ligand for PPARγ.{1424} Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and .DELTA.12-PGJ2 occurs via glutathione addition across the α,β unsaturated enone.{7193} CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 µM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 µM.{12676}

Formal name: 11-oxo-prosta-5Z,12E,14Z-trien-1-oic acid

Synonyms:  9,10-dihydro-15-deoxy-Δ12,14-PGJ2|9,10-dihydro-15-deoxy-Δ12,14-Prostaglandin J2

Molecular weight: 318.5

CAS: 596104-94-8

Purity: ≥98% (isomer mixture)

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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