Description
Highly selective COX-2 inhibitor (IC50 50 >500 µM (COX-1)
Formal name: 3-[4-(methylsulfonyl)phenyl]-4-phenyl-5-(trifluoromethyl)-isoxazole
Synonyms:
Molecular weight: 367.4
CAS: 340267-36-9
Purity: ≥98%
Formulation: A crystalline solid
CAY10404 – 1 mg
Brand:
Cayman
CAS:
340267-36-9
Storage:
-20
UN-No:
Non-Hazardous - /
Many non-steroidal anti-inflammatory drugs (NSAIDs) are potent but non-selective inhibitors of both COX-1 and COX-2 in humans.{1286} CAY10404 is one of the most selective inhibitors of COX-2 which has been reported to date, with a selectivity index (SI; SI = IC50 COX-1/IC50 COX-2) of >500,000. (The COX-1 IC50 is >500 mM, and COX-2 IC50 is 2 inhibitors, and is comparable to the SI of second generation selective COX-2 inhibitors, such as valdecoxib and etoricoxib.{8926}
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