Description
An inhibitor of HDAC (IC50 = 10 µM)
Formal name: 4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]-benzamide
Synonyms: MD 85|PX 089274
Molecular weight: 293.4
CAS: 193551-00-7
Purity: ≥98%
Formulation: A crystalline solid
CAY10398 – 5 mg
Brand:
Cayman
CAS:
193551-00-7
Storage:
-20
UN-No:
Non-Hazardous - /
CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 µM.{8714} Similar potency is observed with trapoxin A and B, whereas trichostatin A is more potent inhibitor of the enzyme. Trichostatin A also selectively inhibits the removal of acetyl groups from the amino-terminal lysine residues of core histones, which modulates the access of transcription factors to the underlying genomic DNA.{4011} However, trichostatin A is much more expensive than CAY10398. CAY10398 thus represents a selective and cost-effective compound for the inhibition of HDAC.
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