An iridoid glycoside; has anti-apoptotic

Catalpol – 1 g

Brand:
Cayman
CAS:
2415-24-9
Storage:
-20
UN-No:
Non-Hazardous - /

Catalpol is an iridoid glycoside that has been isolated from R. glutinosa and has diverse biological activities, including anti-apoptotic, pro-angiogenic, and radioprotective properties.{41802} It protects against mitochondrial pathway-dependent apoptosis in PC12 rat adrenal pheochromocytoma cells and H9c2 rat embryonic ventricular myocardial cells when used at a concentration of 10 µM.{41800,41801} Catalpol pretreatment reduces apoptosis and improves viability in AHH-1 human lymphocyte cells exposed to ionizing radiation and reduces intestinal damage induced by radiation in mice when used at concentrations and doses ranging from of 25 to 100 µg/ml and 25 to 100 mg/kg, respectively.{41799} In a rat model of stroke, catalpol (5 mg/kg, i.p.) increases the expression of erythropoietin and VEGF and improves angiogenesis in the brain.{41803}  

 

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SKU: 24925 - 1 g Category:

Description

An iridoid glycoside; has anti-apoptotic, pro-angiogenic, and radioprotective properties; protects against mitochondrial pathway-dependent apoptosis in PC12 rat adrenal pheochromocytoma cells and H9c2 rat embryonic ventricular myocardial cells at a concentration of 10 µM; pretreatment at concentrations of 25-100 µg/ml reduces apoptosis and improves viability in AHH-1 human lymphocyte cells exposed to ionizing radiation; reduces radiation-induced intestinal damage in mice pretreated at doses of 25-100 mg/kg, i.p.; improves angiogenesis in a rat model of stroke by increasing erythropoietin and VEGF expression in the brain at a dose of 5 mg/kg, i.p.

Formal name: 1aS,1bS,2S,5aR,6S,6aS-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl, β-D-glucopyranoside

Synonyms:  7,8-epoxy Aucubin|Catalpinoside

Molecular weight: 362.3

CAS: 2415-24-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Glycosides||Research Area|Neuroscience

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