Antigen: human caspase-9 amino acids 299-318 • Host: rabbit • Application(s): WB • Caspase-9 is activated by granzyme B

Caspase-9 Polyclonal Antibody – 1 ea

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Cayman
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Apoptosis is related to many diseases and is induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf3.{6864,6865,6874} Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation.{6874} Caspase-9 is also activated by granzyme B and CPP32.{6864,6865} Activated caspase-9 cleaves and activates caspase-3, one of the key proteases responsible for the proteolytic cleavage of many key proteins in apoptosis.{6874} Caspase-9 plays a central role in cell death induced by a wide variety of apoptosis inducers including TNF-α, TRAIL, anti-CD-95, FADD, and TRADD.{6863} Caspase-9 is expressed in a variety of human tissues.{6864,6865}  

 

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SKU: 160790 - 1 ea Category:

Description

Antigen: human caspase-9 amino acids 299-318 • Host: rabbit • Application(s): WB • Caspase-9 is activated by granzyme B, CPP32, or by binding Apaf-1. Activated caspase-9 cleaves and activates caspase-3, playing a central role in cell death induced by a wide variety of apoptosis inducers including TNF-α, TRAIL, anti-CD95, FADD, and TRADD.

Synonyms: Apaf-3|ICE-LAP6|MCH6

Immunogen: synthetic peptide from the C-terminal region of human protein

Formulation: 500 µl of peptide-affinity purified antibody

Isotype:

Applications: WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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