Description
Apoptosis is related to many diseases and is induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf3.{6864,6865,6874} Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation.{6874} Caspase-9 is also activated by granzyme B and CPP32.{6864,6865} Activated caspase-9 cleaves and activates caspase-3, one of the key proteases responsible for the proteolytic cleavage of many key proteins in apoptosis.{6874} Caspase-9 plays a central role in cell death induced by a wide variety of apoptosis inducers including TNF-α, TRAIL, anti-CD-95, FADD, and TRADD.{6863} Caspase-9 is expressed in a variety of human tissues.{6864,6865}
Synonyms: Apaf-3|ICE-LAP6|MCH6
Immunogen: synthetic peptide from the C-terminal region of human protein
Formulation: 500 µl of peptide-affinity purified antibody
Isotype:
Applications: WB
Origin: Animal/Rabbit
Stability: 365 days
Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases
