Caspase-1 Monoclonal Antibody (Clone 14F468) – 1 ea

Brand:
Cayman
Storage:

Antigen: synthetic peptide corresponding to human caspase-1 within the region of amino acids 371-390 • Host: mouse, clone 14F468 • Isotype: IgG1κ • Cross Reactivity: (+) human and mouse caspase-1 • Application(s): IHC (paraffin-embedded sections) and WB • Caspase-1 is similar to the cell death gene CED-3 of C. elegans and regulates multiple proinflammatory cytokines, including interleukin-1β and interferon-γ-inducing factor.  

 

SKU: 13907- 1 ea Category:

Description

Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis.{1642} The precursor form of all caspases is composed of a prodomain and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a tetramer to form the active enzyme. Caspase-1 is similar to the cell death gene CED-3 of C. elegans and regulates multiple proinflammatory cytokines, including interleukin-1β and interferon-γ-inducing factor.


Synonyms: IL-1β Converting Enzyme

Immunogen: synthetic peptide corresponding to human Caspase-1 within the region of amino acids 371-390

Formulation: 100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide

Isotype: IgG1κ

Applications: IHC (paraffin-embedded sections) and WB

Origin:

Stability: 365 days


Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cell Biology|Cell Death|Pyroptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Immunology & Inflammation