Description
A β-adrenergic receptor antagonist (Kd = 13 nM); blocks isoproterenol-induced increases in heart rate, contractile force, and blood pressure in vagotomized dogs (ED50s = 2.3, 3.1, and 1.8 µg/kg, respectively); the (R) and (S)-enantiomers each reduce intraocular pressure in rabbits (1% solution)
Formal name: 5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-2(1H)-quinolinone, monohydrochloride
Synonyms: NSC 300906|OPC 1085
Molecular weight: 328.8
CAS: 51781-21-6
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Neuroscience|Ophthalmology