A selective inhibitor of acid ceramidase (IC50 = 79 nM for rat acid ceramidase); reduces acid ceramidase activity and induces intracellular accumulation of various ceramide species in SW403 colon and LNCaP prostate cancer cells; induces apoptosis in SW403 cells without inhibiting DNA synthesis (IC50 = 1

Carmofur – 1 g

Brand:
Cayman
CAS:
61422-45-5
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Carmofur is an inhibitor of acid ceramidase (IC50 = 79 nM for the rat enzyme) and a derivative of 5-flurouracil (Item No. 14416).{22147} It reduces acid ceramidase activity in a dose- and time-dependent manner and induces intracellular accumulation of various ceramide species, including C18 ceramide (Item No. 19556), C16 ceramide (Item No. 24426), and C14 ceramide (Item No. 22531) in SW403 colon and LNCaP prostate cancer cells. Carmofur induces apoptosis in SW403 cells without inhibiting DNA synthesis (IC50 = 1,212 mM for human thymidylate synthetase). It also reduces acid ceramidase activity and increases ceramide accumulation in mouse lung and brain when administered at doses of 10 and 30 mg/kg.  

 

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Description

A selective inhibitor of acid ceramidase (IC50 = 79 nM for rat acid ceramidase); reduces acid ceramidase activity and induces intracellular accumulation of various ceramide species in SW403 colon and LNCaP prostate cancer cells; induces apoptosis in SW403 cells without inhibiting DNA synthesis (IC50 = 1,212 mM for human thymidylate synthetase); reduces acid ceramidase activity and increases ceramide accumulation in mouse lung and brain at 10 and 30 mg/kg

Formal name: 5-fluoro-N-hexyl-3,4-dihydro-2H,4-dioxo-1-pyrimidinecarboxamide

Synonyms:  HCFU

Molecular weight: 257.3

CAS: 61422-45-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Cancer|Cell Death|Apoptosis

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