An antiepileptic agent; dose-dependently reduces spike and wave discharges in the frontoparietal cortex in a rat model of absence seizures at doses of 10-60 mg/kg; increases latency to the first running episode in the Wistar audiogenic sensitive rat model of convulsive seizures; reduces motor seizure frequency in a rat model of spontaneous seizures in a dose-dependent manner; blocks Nav1.2 channels (IC50 = 68 μM for rat channels); inhibits repetitive firing of action potentials in rat hippocampal neurons in a dose-dependent manner; reduces T-type Ca2+ currents in HEK cells transfected with human recombinant Cav3.1 channels at a concentration of 300 μM

Carisbamate – 500 µg

Brand:
Cayman
CAS:
194085-75-1
Storage:
4
UN-No:
Non-Hazardous - /

Carisbamate is an antiepileptic agent.{37173},{37174} In vivo, administration of carisbamate (10-60 mg/kg) dose-dependently reduces spike and wave discharges in the frontoparietal cortex in a rat model of absence seizures.{37173} Carisbamate (10 mg/kg) increases latency to the first running episode in the Wistar audiogenic sensitive rat model of convulsive seizures. It also reduces motor seizure frequency in a rat model of spontaneous seizures in a dose-dependent manner.{37174} Carisbamate blocks Nav1.2 channels (IC50 = 68 μM for rat channels) and inhibits repetitive firing of action potentials in rat hippocampal neurons in a dose-dependent manner.{37175} It also reduces T-type Ca2+ currents in HEK cells transfected with human recombinant Cav3.1 channels at a concentration of 300 μM.{37176}  

 

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Description

An antiepileptic agent; dose-dependently reduces spike and wave discharges in the frontoparietal cortex in a rat model of absence seizures at doses of 10-60 mg/kg; increases latency to the first running episode in the Wistar audiogenic sensitive rat model of convulsive seizures; reduces motor seizure frequency in a rat model of spontaneous seizures in a dose-dependent manner; blocks Nav1.2 channels (IC50 = 68 μM for rat channels); inhibits repetitive firing of action potentials in rat hippocampal neurons in a dose-dependent manner; reduces T-type Ca2+ currents in HEK cells transfected with human recombinant Cav3.1 channels at a concentration of 300 μM

Formal name: (1S)-1-(2-chlorophenyl)-1,2-ethanediol, 2-carbamate

Synonyms:  JNJ-10234094|RWJ 333369

Molecular weight: 215.6

CAS: 194085-75-1

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Seizure Disorders

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