A tyrosinase inhibitor (IC50 = 56 µM); found in cashew nut shell liquid; halts the cell cycle at the S phase

Cardanol monoene – 10 mg

Brand:
Cayman
CAS:
501-26-8
Storage:
-20
UN-No:
Non-Hazardous - /

Cardanol monoene is a phenol found in cashew nut shell liquid that reversibly inhibits tyrosinase with an IC50 value of 56 µM in vitro.{39262} It halts the cell cycle at the S phase and inhibits proliferation dose- and time-dependently in M14 melanoma cells (IC50s = 23.15 and 12.30 µM after 24 and 48 hours of treatment, respectively).{39253} Cardanol monoene also induces apoptosis via the intrinsic pathway following the accumulation of reactive oxygen species (ROS). A mixture of cardanol mono-, di-, and triene is used to synthesize cardanol-metal complexes that inhibit uropathogenic E. coli biofilm formation.{39263}  

 

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SKU: 23154 - 10 mg Category:

Description

A tyrosinase inhibitor (IC50 = 56 µM); found in cashew nut shell liquid; halts the cell cycle at the S phase, induces ROS accumulation and apoptosis, and inhibits proliferation dose- and time-dependently in melanoma cells (IC50s = 23.15 and 12.30 µM after 24 and 48 hours of treatment, respectively); used as a mixture with cardanol di- and triene to synthesize cardanol-metal complexes that inhibit biofilm formation,

Formal name: 3-8Z-pentadecen-1-yl-phenol

Synonyms:  Cardanol C15:1

Molecular weight: 302.5

CAS: 501-26-8

Purity: ≥98%

Formulation: A neat oil

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Cycle|G2/S||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Tumor Microenvironment||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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